Web8. jan 2024 · High TopBP1 mRNA and protein expression is associated with endometrial cancer. Studies identify the SIRT1-TopBP1 axis as a key signaling mode in the regulation … Web18. mar 2024 · Opto-TopBP1 was expressed in cells at close to the level of endogenous TopBP1. Furthermore, endogenous TopBP1 also formed similar DNA damage-induced condensates, which would presumably correspond to previously described foci.
In vivo formation of gamma-H2AX and 53BP1 DNA repair foci in ... - PubMed
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TOPBP1 - Wikipedia
Web17. aug 2015 · Persistent TopBP1 foci transition into 53BP1 nuclear bodies (NBs) in G1 and precise temporal depletion of TopBP1 just before mitotic entry induced formation of 53BP1 NBs in the next cell cycle, showing that TopBP1 acts to reduce transmission of DNA damage to G1 daughter cells. Web10. aug 2001 · Topoisomerase IIbeta-binding protein (TopBP1), a human protein with eight BRCT domains, is similar to Saccharomyces cerevisiae Dpb11 and Schizosaccharomyces … Web12. jan 2004 · Mammalian TopBP1 is a BRCT domain–containing protein whose function in mitotic cells is linked to replication and DNA damage checkpoint. Here, we study its possible role during meiosis in mice. TopBP1 foci are abundant during early prophase I and localize mainly to histone γ-H2AX–positive domains, where DNA double–strand breaks (required … bothell business school