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Topbp1 foci

Web8. jan 2024 · High TopBP1 mRNA and protein expression is associated with endometrial cancer. Studies identify the SIRT1-TopBP1 axis as a key signaling mode in the regulation … Web18. mar 2024 · Opto-TopBP1 was expressed in cells at close to the level of endogenous TopBP1. Furthermore, endogenous TopBP1 also formed similar DNA damage-induced condensates, which would presumably correspond to previously described foci.

In vivo formation of gamma-H2AX and 53BP1 DNA repair foci in ... - PubMed

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TOPBP1 - Wikipedia

Web17. aug 2015 · Persistent TopBP1 foci transition into 53BP1 nuclear bodies (NBs) in G1 and precise temporal depletion of TopBP1 just before mitotic entry induced formation of 53BP1 NBs in the next cell cycle, showing that TopBP1 acts to reduce transmission of DNA damage to G1 daughter cells. Web10. aug 2001 · Topoisomerase IIbeta-binding protein (TopBP1), a human protein with eight BRCT domains, is similar to Saccharomyces cerevisiae Dpb11 and Schizosaccharomyces … Web12. jan 2004 · Mammalian TopBP1 is a BRCT domain–containing protein whose function in mitotic cells is linked to replication and DNA damage checkpoint. Here, we study its possible role during meiosis in mice. TopBP1 foci are abundant during early prophase I and localize mainly to histone γ-H2AX–positive domains, where DNA double–strand breaks (required … bothell business school

Functions of TopBP1 in preserving genome integrity during mitosis

Category:TopBP1 comes into focus: Molecular Cell

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Topbp1 foci

TopBP1 assembles nuclear condensates to switch on ATR signaling

Web11. nov 2024 · Together, these data hinted that CIP2A collaborates with MDC1 and TOPBP1 to promote the accurate segregation of damaged chromosomes. In support of this … WebCombined TOPBP1 immunostaining and FISH for rDNA repeats corroborated these results; large nucleolar TOPBP1 foci were covered with dot-like rDNA FISH signals (Fig. 1 E). SIM studies revealed that in most APH-treated HeLa cells, TOPBP1 formed one large focus inside the nucleolus (Fig. 1 F) that corresponded to the large FC, as evidenced by ...

Topbp1 foci

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Web28. máj 2024 · BRCT domains of TOPBP1 selectively bind conserved phosphorylation sites in the N-terminus of 53BP1. Mutation of these sites does not affect formation of 53BP1 … Web24. sep 2010 · TopBP1 is a checkpoint protein that colocalizes with ATR at sites of DNA replication stress. In this study, we show that TopBP1 also colocalizes with 53BP1 at sites of DNA double-strand breaks (DSBs), but …

Web18. jan 2024 · It was reported that 53BP1 spontaneous foci were mainly presented in G phase cells and will be resolved during late G1 to S phase through DSB repair … Web2. aug 2024 · The role of TOPBP1 goes beyond the typical replication stress response; it interacts with the low-complexity nucleolar protein Treacle (also referred to as TCOF1) and forms large Treacle-TOPBP1 foci inside the nucleolus.

Web26. jan 2024 · We induced TopBP1 condensation during the CldU pulse using two cycles of 3 min blue light illumination, in order to actuate and maintain TopBP1 foci during the 20 min labeling period (Figure 5E). DNA replication tracks labeled in the presence of optogenetic TopBP1 condensates were shorter than DNA replication tracks labeled in the absence of ... Web7. nov 2011 · The checkpoint is enforced by ATR-dependent phosphorylation of CHK1, which is mediated by the TIMELESS-TIPIN complex and CLASPIN. Although loss of checkpoint proteins is associated with spontaneous...

Web1. jan 2002 · We report here that TopBP1 is phosphorylated in response to DNA double-strand breaks and replication blocks. TopBP1 forms nuclear foci and localizes to the sites of DNA damage or the arrested replication forks. In response to DNA strand breaks, TopBP1 phosphorylation depends on the ataxia telangiectasia mutated protein (ATM) in vivo.

Web18. mar 2024 · TopBP1 drives the formation of micrometer-sized nuclear condensates TopBP1 forms nuclear foci upon entry into mitosis ( Leimbacher et al., 2024; Pedersen et … hawthorne \\u0026 associatesWeb( Dc ) TopBP1 foci are seen in an MRL dermal cell nucleus. Source publication Lack of p21 expression links cell cycle control and appendage regeneration in mice [Cell_Biology] hawthorne \\u0026 hawthorneWeb15. jan 2024 · We found that TopBP1 deletion caused reduced testis size, reduced epididymal sperm numbers, increased apoptosis, and severely compromised fertility. Loss of TopBP1 in testicular germ cells caused defects in DMC1 and Rad51 foci formation, abnormal SC and meiotic chromosome defects. bothell cab service