Ews atf1
WebOf the 12 cases positive for a split EWSR1 signal, 6 showed rearrangement of ATF1 (50%) (Fig. 7B), 3 showed rearrangement of CREB1 (25%), 2 showed no rearrangements of either ATF1 or CREB1 genes, and in 1 case ATF1 and CREB1 were not evaluated (case 16). One case showed no involvement of EWSR1, ATF1, or CREB1 by FISH WebJan 18, 2013 · The ability of this gene to produce a fusion transcript with EWS has been demonstrated in clear-cell sarcoma, defined in the past as malignant melanoma of soft parts (MMSP) [57, 58] More recently, EWS/ATF-1 has been described in soft tissue and angiomatoid fibrous histiocytoma [59–61], and in Hyalinizing clear-cell carcinoma …
Ews atf1
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WebCyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an activating transcription factor, which belongs to … WebClear cell sarcoma (CCS) is associated with the EWS/ATF1 oncogene that is created by aberrant t(12;22)(q13;q12) chromosomal fusion of the Ewings Sarcoma oncogene (EWS) and the cellular transcription factor ATF1. SU-CCS-1 cell line has been revealed to express the EWS/ATF1 fusion protein, and been used as a valuable tool to study CCS biology …
WebAt least four major EWSR1/ATF1 splicing variants have been described ( Figure 26-5 ). Type 1 is the most common and results in fusion of EWSR1 exon 8 to ATF1 exon 4 … WebCharles Leclerc Urges Fans To Stay Away From His Home After ‘Crossed Boundaries’
To establish iPSCs, we introduced OCT3/4, SOX2, KLF4 and cMYC into a murine CCS cell line (G1297) containing doxycycline (Dox)-controllable EWS/ATF1 alleles9. iPSC-like colonies were picked up to establish iPSC-like cell lines (Fig. 1a). The established iPSC-like clones showed elevated activity of alkaline phosphatase … See more We next examined secondary sarcoma development11,12 in sarcoma-iPSC chimeric mice by inducing EWS/ATF1. For control experiments, chimeric mice were generated with embryonic stem cells (ESCs) and iPSCs, … See more Immunohistochemical analysis revealed that EWS/ATF1 is expressed in various organs and tissues of sarcoma-iPSC mice after Dox treatment (day 5, Supplementary Fig. 3a). Notably, … See more It has been reported that human CCSs harbor shared properties with malignant melanomas6. Consistently, previous studies demonstrated a similarity in the global gene … See more Taking advantage of the one-step and cell-type-specific nature of secondary sarcoma development in sarcoma-iPSC mice, we next attempted to … See more WebMar 29, 2001 · The EWS/ATF1 and EWS/FLI1 fusion proteins associated with Clear Cell Sarcoma and Ewing's Sarcoma, respectively, were utilized to study the comparative effect of the EWS component on two different ...
WebBecause the EWS-ATF1 fusion transcript and the associated t (12;22) (q13;q12) translocation occur in CCS but not cutaneous melanoma, we investigated the use of …
div height propertyWebEWS Is Part of a Family of Genes Frequently Rearranged in Sarcoma and Leukemia and Predisposing to Familial Amyotrophic Lateral Sclerosis. ... At least four major EWSR1/ATF1 splicing variants have been described (Figure 26-5). Type 1 is the most common and results in fusion of EWSR1 exon 8 to ATF1 exon 4 ... div height scrollWebSep 9, 2003 · ATF1 is expressed at low levels in the CCS cells tested, while EWS/ATF1 (as indicated by an ∼ 80 kDa polypeptide that binds to the ATF1 DNA affinity resin, reacts with a c-terminal ATF1 antibody ... div height width